Molecular Oncology, Cancer Diagnostics and Therapeutics, Immunology, Phytotherapeutics, Exosomes and Biomarkers Research

• B. Sc. , 2012 , University of Delhi
• M. Sc. , 2014 , University of Delhi
• M. Phil. , 2016 , University of Delhi
• Ph. D. , 2022 , University of Delhi

Teaching Experience (2015-22): 7 Years of assisted supervision of M. Sc. students for classes and practical lab work during Ph.D. tenure.

Thesis Title: Investigation of Molecular Mechanism(s) of STAT3-Mediated Regulation of HPV Infection and Cervical Carcinogenesis

Salient features of Ph.D. research work
Cervical cancer is a major threat among women in the developing countries, which is caused by the persistent infection of high-risk human papillomaviruses (HR-HPVs). The Ph.D. research work entitled 'Investigation of Molecular Mechanism(s) of STAT3-Mediated Regulation of HPV Infection and Cervical Carcinogenesis' provides a comprehensive analysis of JAK-STAT signaling components in cervical cancer patients tissue biopsy samples. Further, the interaction of HR-HPVs with Signal transducer and activator of transcription 3 (STAT3) was established in order to understand the role of STAT3 in transcriptional regulation of HR-HPVs.

1      Thakur, K., Singh, T., Sharma, D., Padha, N., Mir, B.A., Chandra, A., and Rajpal, V.R.: ‘Exploring the Therapeutic Potential of Traditional Medicinal Foods in Cancer Treatment: Molecular Evidence and Bioactivities’, Curr Top Med Chem, 2024

2      Senrung, A., Tripathi, T., Aggarwal, N., Janjua, D., Chhokar, A., Yadav, J., Chaudhary, A., Thakur, K., Singh, T., and Bharti, A.C.: ‘Anti-angiogenic Potential of Trans-chalcone in an In Vivo Chick Chorioallantoic Membrane Model: An ATP Antagonist to VEGFR with Predicted Blood-brain Barrier Permeability’, Cardiovasc Hematol Agents Med Chem, 2024, 22, (2), pp. 187-211

3      Janjua, D., Thakur, K., Aggarwal, N., Chaudhary, A., Yadav, J., Chhokar, A., Tripathi, T., Joshi, U., Senrung, A., and Bharti, A.C.: ‘Prognostic and therapeutic potential of STAT3: Opportunities and challenges in targeting HPV-mediated cervical carcinogenesis’, Crit Rev Oncol Hematol, 2024, 197, pp. 104346

4      Grover, P., Thakur, K., Bhardwaj, M., Mehta, L., Raina, S.N., and Rajpal, V.R.: ‘Phytotherapeutics in Cancer: From Potential Drug Candidates to Clinical Translation’, Curr Top Med Chem, 2024, 24, (12), pp. 1050-1074

5      Thakur, K., Janjua, D., Aggarwal, N., Chhokar, A., Yadav, J., Tripathi, T., Chaudhary, A., Senrung, A., Shrivastav, A., and Bharti, A.C.: ‘Physical interaction between STAT3 and AP1 in cervical carcinogenesis: Implications in HPV transcription control’, Biochim Biophys Acta Mol Basis Dis, 2023, 1869, (8), pp. 166817

6      Singh, T., Aggarwal, N., Thakur, K., Chhokar, A., Yadav, J., Tripathi, T., Jadli, M., Bhat, A., Kumar, A., Narula, R.H., Gupta, P., Khurana, A., and Bharti, A.C.: ‘Evaluation of Therapeutic Potential of Selected Plant-Derived Homeopathic Medicines for their Action against Cervical Cancer’, Homeopathy, 2023, 112, (4), pp. 262-274

7      Thakur, K., Janjua, D., Shishodia, G., Chhokar, A., Aggarwal, N., Yadav, J., Tripathi, T., Chaudhary, A., Senrung, A., and Bharti, A.C.: ‘Investigation of molecular mechanisms underlying JAK/STAT signaling pathway in HPV-induced cervical carcinogenesis using 'omics' approach’, Med Oncol, 2022, 39, (12), pp. 255

8      Bhat, A., Yadav, J., Thakur, K., Aggarwal, N., Chhokar, A., Tripathi, T., Singh, T., Jadli, M., Veerapandian, V., and Bharti, A.C.: ‘Transcriptome analysis of cervical cancer exosomes and detection of HPVE6*I transcripts in exosomal RNA’, BMC Cancer, 2022, 22, (1), pp. 164

9      Tripathi, A., Kashyap, A., Tripathi, G., Yadav, J., Bibban, R., Aggarwal, N., Thakur, K., Chhokar, A., Jadli, M., Sah, A.K., Verma, Y., Zayed, H., Husain, A., Bharti, A.C., and Kashyap, M.K.: ‘Tumor reversion: a dream or a reality’, Biomark Res, 2021, 9, (1), pp. 31

10    Singh, T., Chhokar, A., Thakur, K., Aggarwal, N., Pragya, P., Yadav, J., Tripathi, T., Jadli, M., Bhat, A., Gupta, P., Khurana, A., and Chandra Bharti, A.: ‘Targeting Aberrant Expression of STAT3 and AP-1 Oncogenic Transcription Factors and HPV Oncoproteins in Cervical Cancer by Berberis aquifolium’, Front Pharmacol, 2021, 12, pp. 757414

11    Jadli, M., Thakur, K., Aggarwal, N., Chhokar, A., Bibban, R., Singh, T., Bhat, A., and Bharti, A.C.: ‘Delineating role of NF-kappaB and interacting cytokines during prostate cancer-induced osteoclastogenesis’, J Cell Biochem, 2021, 122, (2), pp. 259-276

12    Bhat, A., Yadav, J., Thakur, K., Aggarwal, N., Tripathi, T., Chhokar, A., Singh, T., Jadli, M., and Bharti, A.C.: ‘Exosomes from cervical cancer cells facilitate pro-angiogenic endothelial reconditioning through transfer of Hedgehog-GLI signaling components’, Cancer Cell Int, 2021, 21, (1), pp. 319

13    Aggarwal, N., Yadav, J., Chhakara, S., Janjua, D., Tripathi, T., Chaudhary, A., Chhokar, A., Thakur, K., Singh, T., and Bharti, A.C.: ‘Phytochemicals as Potential Chemopreventive and Chemotherapeutic Agents for Emerging Human Papillomavirus-Driven Head and Neck Cancer: Current Evidence and Future Prospects’, Front Pharmacol, 2021, 12, pp. 699044

14    Aggarwal, N., Yadav, J., Thakur, K., Bibban, R., Chhokar, A., Tripathi, T., Bhat, A., Singh, T., Jadli, M., Singh, U., Kashyap, M.K., and Bharti, A.C.: ‘Human Papillomavirus Infection in Head and Neck Squamous Cell Carcinomas: Transcriptional Triggers and Changed Disease Patterns’, Front Cell Infect Microbiol, 2020, 10, pp. 537650

15    Shukla, S., Jadli, M., Thakur, K., Shishodia, G., Mahata, S., Basir, S.F., Das, B.C., and Bharti, A.C.: ‘Level of phospho-STAT3 (Tyr705) correlates with copy number and physical state of human papillomavirus 16 genome in cervical precancer and cancer lesions’, PLoS One, 2019, 14, (9), pp. e0222089