Biochemistry, Molecular Biology, Cell Biology, Ubiquitin, Mitochondrial Biology and Protein Quality Control

• BSc , 2002 , Himachal Pradesh University, Shimla
• MSc , 2004 , School of Life Sciences, Jawharlal Nehru University , New Delhi
• PhD , 2011 , School of Life Sciences, Jawharlal Nehru University , New Delhi
• , ,

1.  Postdoctoral Fellow( Apreil,2011- April 2013) :  Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, USA 

 Area of Research : Cardiovascular and Mitochondrial research.

2. Postdoctoral Fellow (April 2013- Dec 2016). : Faculty of Biology,  Israel Institute of Technolohy,Technion, Israel.

Area of Research : Ubiquitin and Mitochondria quality control

Molecular Biology, Biochemistry

PhD (Life Sciences) from the School of Life Sciences, Jawaharlal Nehru University, New Delhi. 
Thesis entitled: Elucidations of the mechanisms of redox signalling leading to cardiac myocytes hypertrophy and apoptosis under adrenergic stress.

Praveen Kumar and Anita Thakur. Phytochemicals in Cancer  Chemoprevention: A Brief Perspective. Springer Nature Singapore Pte Ltd. 2020 https://doi.org/10.1007/978-981-15-5999-0_1.

• Thakur A, Alam MJ, Ajayakumar MR, Ghaskadbi S, Sharma M, Goswami SK. Norepinephrine-induced apoptotic and hypertrophic responses in H9c2 cardiac myoblasts are characterized by different repertoire of reactive oxygen species generation. Redox Biol. 2015 Aug;5:243-252. doi: 10.1016/j.redox.2015.05.005. (Impact Factor: 11.799) 
• Chang HC, Wu R, Shang M, Sato T, Chen C, Shapiro JS, Liu T, Thakur A, Sawicki KT, Prasad SV, Ardehali H. Reduction in mitochondrial iron alleviates cardiac damage during injury. EMBO Mol Med. 2016 Mar 1;8(3):247-67. doi: 10.15252/emmm.201505748. (Impact Factor: 12.137)
• Nakasone MA, Lewis TA, Walker O, Thakur A, Mansour W, Castañeda CA, Goeckeler-Fried JL, Parlati F, Chou TF, Hayat O, Zhang D, Camara CM, Bonn SM, Nowicka UK, Krueger S, Glickman MH, Brodsky JL, Deshaies RJ, Fushman D. Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway. Structure. 2017 Dec 5;25(12):1839-1855.e11. doi: 10.1016/j.str.2017.10.007.(Impact Factor:5.006)
• Sulkshane P, Duek I, Ram J, Thakur A, Reis N, Ziv T, Glickman MH. Inhibition of proteasome reveals basal mitochondrial ubiquitination. J Proteomics. 2020 Oct 30;229:103949. doi: 10.1016/j.jprot.2020.103949. Impact factor: 4.004)
• Prasad Sulkshane, Jonathan Ram, Anita Thakur, Noa Reis, Oded Kleifeld, Michael H Glickman. Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia. Redox Biol 2021 Sep;45:102047. (Impact Factor: 11.799)
• SylviaZerath Gurevich, Abhishek Sinha, Joseph Longworth, RajeshK. Singh, BetsegawE. Lemma, Anita Thakur, Oliver Popp, Daniel Kornitzer, Noa Reis, Martin Scheffner, Gunnar Dittmar, Elah Pick, David Fushman, Michael H. Glickman. Rub1/NEDD8, a ubiquitin-like modifier, is also a ubiquitin modifier. Biorxiv (2020)  doi: https://doi.org/10.1101/2020.06.18.159145

ABSTRACT PUBLISHED IN CONFERENCES

• M Bayeva, A Thakur, R Wu, X Chai, H Ardehali. Mitochondrial Iron Accumulation Leads to Cardiomyocyte Death and its Levels are Directly Sensed in the Cytoplasm. Circulation 2013 128 (suppl_22), A14187- A14187  (Impact factor: 29.69)
• A Thakur, M Bayeva, H Ardehali. Role of the Mitochondrial Iron in Cardiomyoblast Survival and Maturation of Cytosolic Fe/S Proteins. Circulation Research 2013 113 (suppl_1), A270-A270 (Impact factor:17.367)

• Poster presented at 7th PROTEASOME & AUTOPHAGY WORKSHOP, 2015: E3 Ubiquitin Ligases Contribute to Mitochondria Adaptation Under Hypoxia.
• Attended the American Heart Association Scientific Sessions 2012 at Los Angeles, CA from 03-08, November 2012.
• Attended the American Heart Association Scientific Sessions 2011 at Orlando, Florida from 12- 16 November 2011.
• Poster Presented at Gordon Research Conference: Cardiac Regulatory Mechanisms on "Distinctive Redox Dynamics Control Adrenergic Signalling in H9c2 Cardiac myoblasts " at Colby- Sawyer College, New London, NH, USA from June 6th -12th, 2010.
• Anita Thakur and Shyamal K Goswami. Norepinephrine Induces Hypertrophy and Apoptosis in Cardiac Myocytes by Distinct Redox Signaling Rather Than a General Surge of ROS. Abstract No 324, page no156 Keystone Symposia: Cardiovascular Development and Repair 2010
• Given poster    presentation     in “13th Transcription Assembly” held at School of Life Sciences, Jawaharlal Nehru University, New Delhi India, 26-27 February 2010.
• Participated in Indo-US Bilateral Workshop on “Redox Signalling in Degenerative Diseases” held at Hertiage Villlage, Manesar, Gurgaon, 19-21December, 2009.
• Oral presentation on “Differential redox signaling in cardiac myocytes under adrenergic stress” at Biosparks; The 7th Annual Research Festival 2009 at School of Life Sciences, Jawaharlal Nehru University, New Delhi India.
• Given poster presentation on “Differential redox signaling in cardiac myocytes under adrenergic stress” at 77th   Annual Meeting of the “Society of Biological Chemists (India)” held on December 18-20, 2008, at IITM, Chennai.
• Participated in the Indo -US Workshop and National Congress on “Molecular Biology and Microbial Bio- Technology” held during March 23-28, 2003 in the School of life Sciences, Jawaharlal Nehru University, New Delhi.

Invited Talk entitled “Ubiquitin is phosphorylated by PINK1 to activate parkin” Technion Ubiquitin Studies Section, Wednesday, July 30, 2014, Biology Auditorium, Technion, Israel

• Full active participation in UPSTREAM ITN WORKSHOP on Proteasome isolation and Detection at Technion, March 2nd-6th, 2014
• Attended the HUJI-Hands-On: Mitochondria Course at Jerusalem January 7th-9th, 2014.
• Anita Thakur and Hossein Ardheali.  Reduction of Mitochondrial Iron by Decreasing Mitochondrial Iron Import or by Iron Chelation can Rescue the Effects of ABCB8 Knockown, Poster presented at 9th Annual North American ABC Genetic Workshop 2012, September 27-28, 2012, held at Frederick National laboratory, USA

Awards

•  PBC Postdoctoral Scholarship from Planning and Budgeting Committee of the Council for Higher Education of Israel from Sept 2012- Sept 30, 2015.
• Won the Best Poster award in 77th Annual Meeting of the “Society of Biological Chemists (India)” held at Indian Institute of Technology Madras (IITM), Chennai from December 18-20, 2008.
• Awarded Senior Research Fellowship from Council of Scientific & Industrial Research (CSIR), India from 2006-2009.
• Awarded Junior Research Fellowship from Council of Scientific & Industrial Research (CSIR), India from 2004-2006.

Professional Memberships

American Heart Association (2011-2013)

COST Proteostasis (2014-2016)