Dr Brijesh Rathi

Assistant Professor | Department of Chemistry Contact (Off.): +91-11-27667458 Email Address : brijeshrathi@hrc.du.ac.in URL : http://hansrajcollege.ac.in/vfp.php?id=28

Specialization

Organic Chemistry

Educational Qualifications Ph.D , 2010 , University of Delhi

Career Profile

Visiting Assistant Professor [August 1, 2016 - July 31, 2017], Department of Chemistry, Massachusetts Institute of Technology (M.I.T.), 77 Massachusetts Avenue, Cambridge, MA 02139 United States of America Assistant Professor [Dec 15, 2014-Till], Department of Chemistry, Hansraj College University Enclave, University of Delhi, Delhi-110007. Assistant Professor [Aug 5, 2010-Dec 14, 2014], Department of Chemistry, Sri Venkateswara College, University of Delhi, New Delhi-110021. Visiting Fellow [June 6-16, 2016], Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. Visiting Fellow [June 30 –July 7, 2016], Belarussian State University, Minsk, Belarus. Visiting Fellow [Oct. 2014], Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal. Principal Investigator [2011-2014], Department of Chemistry, University of Delhi, Delhi-110007 Title of the Project: “Novel functionalized tetrahedral activated small peptidomimetic inhibitors of malarial aspartic proteases, plasmepsin I and plasmepsin II” Funding Agency: Department of Science and Technology, Ministry of Science and Technology, Government of India.

Subjects taught

Basic Organic Chemistry, Chemistry of Biomolecules, Environmental Chemistry etc.

Administrative Assignments

Member of Hostel Committee, 2015-16

Thesis

Synthesis, Conformational Features and Reactivity Studies of Sym N,N’,N”-Triarylguanidines (2010)

Journals Articles

1.Kumar, P.; Achieng, A. O.; Rajendran, V.; Ghosh, P.; Singh, B.K.; Rawat, M.; Perkins, Douglas J.; Kempaiah,P.; Rathi, B.* "Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model" Sci. Rep. 2017 Accepted DOI:10.1038/s41598-017-06097-z (IF, 5.228; Nature Group Publications). 2. Gorobets, N.; Yuriy S.; Singh B.; Poonam and Rathi, B. (*) An Overview of Currently Available Antimalarials Curr. Topics Med. Chem. 2017 In Press (IF: 2.90; ISSN: 1568-0266). 3. Editorial: Rathi, B.; Feletrov, Y.; Latha, N.; Poonam and Vladimir, S. “New Avenues in Controlling Infectious Diseases” Curr. Topics Med. Chem. 2017 (IF: 2.90; ISSN: 1568-0266). 4. Renuka, N.; Babu, R.; Vijayan, N.; Rathi, B.; Thukral, K. "Effect of Oxygen Ion Irradiation on the Structural and Optical Properties of L-Arginine Acetate Single Crystals" Recent Trends in Material Science and Application 2017, 511-519 (Springer, ISBN: 978-3-319-44890-9). 5. Singh, A.; Bhardwaj, J.; Olival, A.; Kumar, Y.; Podder, A.; Maheshwari, A.; Latha, N.; Singh, B. K.; Tomás, H.; Rodrigues, J.; Rathi, B. (*) “Design, Synthesis and Biological Evaluation of Arylpiperazine Based Novel Phthalimides: Active Inducers of Testicular Germ Cell Apoptosis” J. Chem. Sci. 2016, 128, 1245-1263 (IF: 1.085; Springer; ISSN: 0973-7103). 6. Singh, A.; Medviediev, V. V.; Shishkin, O.; Bahadur, V.; Singh, T.; Singh, B. K.; Vijayan, N.; Balachandran, V.; Gorobets, Yu N. and Rathi, B. (*) “Functionalized Organic Frameworks Explored As Second Order NLO Agents” J. Chem. Sci. 2016, 128, 297-309 (IF: 1.191; Springer; ISSN: 0973-7103). 7. Gupta, N.; Gupta, C.; Sharma, S.; Rathi, B.; Sharma, R. K. and Bohidar, H. B. “Magnetic iron oxide nanoparticles encapsulating horseradish peroxidase (HRP): synthesis, characterization and carrier for the generation of free radicals for potential applications in cancer therapy” RSC Adv. 2016, 6, 111099 (IF: 3.289; Royal Society of Chemistry, UK; ISSN: 2046-2069). 8. Meet Our Editorial Board Member, Curr. Topics Med. Chem., 2016, 16, 895-896 (IF: 2.9; ISSN: 1568-0266). 9. Singh, A. K.; Rathore, S.; Tang, Y.; Goldfarb, N. E.; Dunn, B. M.; Rajendran, V.; Ghosh, P. C.; Latha, N.; Singh, B. K. and Rathi, B. (*) “Hydroxyethylamine Based Phthalimides As New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial Evaluation” Plos ONE 2015, 10, e0139347 [IF: 4.4 (2010); Plos; ISSN: eISSN-1932-6203]. 10. Singh, A. K.; Rajendran, V.; Ghosh, P. C.; Singh, N.; Latha, N.; Garg, S.; Pandey, K. C.; Singh, B. K.; Rathi, B. (*) “Design, Synthesis and Biological Evaluation of Functionalized Phthalimides: A New Class of Antimalarials and Inhibitors of Falcipain-2, a Major Hemoglobinase of Malaria Parasite” Bioorg. Med. Chem. Accepted 2015, 23, 1817–1827 (IF: 2.9521; Elsevier; ISSN: 0968-0896). 11. Editorial: Rodrigues, J. and Rathi, B. “Self-assembled Organic Nanostructures in Medicinal Chemistry: Advances and Applications” Curr. Topics Med. Chem. 2015, 15, 1161-1161 (IF: 2.90; ISSN: 1568-0266). 12. Sharma, P.; Rathi, B.; Rodrigues, J.; Gorobets, Yu. N. “Self-Assembled Peptide Nanoarchitectures: Applications and Future Aspects” Curr. Topics Med. Chem. 2015, 15, 1268-1289 (IF: 3.40; ISSN: 1568-0266). 13. Sharma, A.; Sharma, S.; Sharma, K.; Chetri, S.; Vashishtha, A.; Singh, P.; Kumar, R.; Rathi, B. and Agarwal, V. “Algae as crucial organisms in advancing nanotechnology: a systematic review” J. Appl. Phycol. 2015, 28, 1759-1774 (IF: 2.56; Citation: 1; Springer, ISSN: 1573-5176). 14. Sharma, P. P.; Kumar, R.; Singh, A.; Singh, B. K.; Kumar, A and Rathi B. (*) “Potentials of Hydrogels in Cancer Therapy” Curr. Cancer Ther. Rev. 2014, 10, 246-270 (Bentham Science Publications; Citation: 1; ISSN: 1875-6301). 15. Rani, R.; Thukral, K.; Krishna, A.; Vijayan, N. Rathi, B. “Synthesis and nucleation studies on L-leucine hydrobromide: a promising nonlinear optical material” J. Appl. Crystallogr. 2014, 47, 1966-1974 (IF: 3.95; ISSN: 1600-5767). 16. Rathi, B.; Sharma, P.; Singh, R. P. “Tetrahedral Hydroxyethylamine: A Privileged Scaffold in Development of Antimalarial Agents” Chem. Biol. Lett. 2014, 1, 11-13 (Indian Science Publications; ISSN: 2347–9825). 17. Singh, A.; Balachandran, V.; Vijayan, N.; Bahadur, V.; Tiwari, H.; Singh, B. and Rathi, B. (*) “Synthesis, Structural Aspects and Nonlinear Optical Properties of Novel Phthalimide Derivatives: Theoretical and Experimental Approach” J. Phys. Org. Chem. 2014, 27, 490-497 (IF: 1.229; Citation: 1; John Wiley & Sons; ISSN: 1099-1395). 18. Krishna, A.; Thukral, K.; Vijayan, N.; Riscob, B.; Haldhar, S.; Rathi, B.; Jacob, P. “Synthesis and single crystal growth of L-proline cadmium chloride monohydrate and its characterization for higher order harmonic generation applications” CrystEngComm, 2014, 16, 2802-2809 (IF: 3.879; Citation: 8; Royal Society of Chemistry, UK; ISSN: 1466-8033). 19. Vijayan, V.; Philip, J.; Haranath, V.; Rathi, B.; Bhagavannarayana, G.; Halder, S.; Roy, N.; Jayalakshmy, M. S. and Verma, S. “Bulk growth of ninhydrin single crystals by solvent evaporation method and its characterization for SHG and THG applications” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2014, 122, 309-314 (IF: 2.098; Citation: 4; Elsevier; ISSN: 1386-1425). 20. Rathi, B. (*); Singh, A.; Kishan, R.; Latha, N.; Pandey, K. C. Tiwari, H. and Singh, B. K. ‘Functionalized hydroxyethylamine based peptide nanostructures as potential inhibitors of falcipain-3, an essential proteases of Plasmodium falciparum’ Bioorg. Med. Chem. 2013, 21, 5503–5509 (IF: 2.9521; Citation: 6; Elsevier; ISSN: 0968-0896). 21. Singh, A.; Kishan, R.; Vijayan, N.; Balachandran, V.; Tiwari, H.; Singh, B. and Rathi, B. (*) “Entry of Chiral Phthalimides With Significant Second Order Nonlinear Optical and Piezoelectric Properties’ RSC Adv., 2013, 3, 14750-14756 (IF: 3.289; Citation: 4; Royal Society of Chemistry, UK; ISSN: 2046-2069). 22. Kishan, R.; Vijayan, N.; Rupini, B.; Singh, R.; Kumar, Y. and Rathi, B. (*) “Structural Aspects, Biological and Nonlinear Optical Response of New N,N′–Di(2-tolyl)formamidinium Tosylate” Adv. Chem. Lett. 2013, 1, 134-139 (Accepted (American Scientific Publishers, USA; ISSN: 2326-7488). 23. Rupini, B.; Sharda, P.; Rathi, B. (*) “Asymmetric Reductive Amination of Carbonyl Compounds by Using N,N,N-Tributylpropanaminium Based Novel Chiral Ionic Liquid” Int. J. Org. Chem., 2013, 3, 190-193. (IF: 0.57; Scientific Research Publishers, USA; ISSN: 2161-4695). 24. Aggarwal, A.; Kumari, R.; Mehla, N.; Deepali, Bhatnagar, S.; Sharma, K.; Sharma, V.; Rathi, B. (*) “Depletion of the Ozone Layer and Its Consequences: A Review” Am. J. Plant Sci., 2013, 4, 1990-1997 (IF: 0.27; Scientific Research Publishers, USA; ISSN: 2158-2750). 25. Rani, N.; Vijayan, N.; Riscob, B.; Jat, S. K.; Das, S.; Bhagwannarayan, G.; Rathi, B.; Wahab, M. A. “Single Crystal Growth of Ninhydrin by Unidirectional Sankaranarayanan-Ramasamy (SR) Method by Using Glass Ampoule For Non-linear Optical Applications” CrystEngComm, 2013, 15, 2127–2132 (IF: 4.069 for five years; Citation: 8; Royal Society of Chemistry, UK; ISSN: 1466-8033). 26. Vijayan, N.; Rani, N.; Madhurambal, G.; Bhagavannarayana, G.; Rathi, B.; Philip, R.; Safakath, K.; Mojumdar, S. C. ‘Synthesis, growth, and characterization of iminodiacetic acid monohydrochloride’ J. Thernal Analysis and Calorimetry 2013, 112, 1113-1119; (IF: 1.604; Citation: 1; Springer; ISSN: 1572-8943). 27. Vijayan, N.; Bhagwannarayan, G.; Halder, S. K.; Verma, S.; Philip, J. Rathi, B. “X-ray Topography, Photopyroelectric and Two-photon Absorption Studies on Solution Grown Benzimidazole Single Crystal” Appl. Phys. A 2013, 110, 55-58 (IF: 1.630; Citation: 3 Springer; ISSN: 1432-0630). 28. Rani, N.; Vijayan, N.; Rathi, B.; Bhagavannarayana, G. “Studies on the effect of polymer coating on solution grown hygroscopic non-linear optical single crystal of L-lysine monohydrochloride” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2012. 97, 871-875 (IF: 2.098; Citation: 2; Elsevier; ISSN: 1386-1425). 29. Vijayan, N.; Bhagavannarayana, G.; Maurya, K. K.; Haranath, D.; Rathi, B.; Balamurgan, N.; Sharma, Y. K.; Ramasamy, P. “Effect of Annealing on Bridgman Grown Organic Scintillation Material of trans-Stilbene” MatChemPhys 2012, 132, 453-457. (IF: 2.234; Elsevier; ISSN: 0254-0584). 30. Renuka, N.; Vijayan, N.; Rathi, B.; Nagarajan, K.; Ramesh Babu, R.; Bhagavannarayana, G. “Synthesis, Growth and Optical Properties of Semi Organic Non-linear Optical Single Crystal: L-Arginine Acetate” OPTIK 2012, 123, 189-192. (IF: 0.510; Citation: 13; Elsevier; ISSN: 0030-4026). 31. Gopi, K.; Rathi, B.; Natesan, T. “Synthesis and Conformational Features of N,N',N"-Triarylguanidines” J. Chem. Sci. 2010, 122, 157-167. (IF: 1.191; Citation: 9; Springer; ISSN: 0973-7103). 32. Mahapatra, S. C.; Tiwari, H. K.; Singla, M.; Rathi, B.; Sharma, A.; Mahiya, K.; Kumar, M.; Sinha, S.; Chauhan, S. S. “Antimalarial Evaluation of Copper(II) Nanohybrid Solids: Inhibition of Plasmepsin II, A Hemoglobin-degrading Malarial Aspartic Protease From Plasmodium falciparum” J. Biol. Inorg. Chem. 2010, 15, 373-385. (IF: 3.164; Citation: 16; Springer; ISSN: 1432-1327). *Corresponding Author

Conference/ Symposium etc. Paper Presented

“Indo-Portuguese workshop on Nanotechnology in Chemistry and Biology (INCB- 2016)” jointly organized by Department of Chemistry, Hansraj College and CQM, University of Madeira, Portugal (February 12-13, 2016). Role: National Coordinator MHRD funded “National Workshop on Role of Technical Terminology in Higher Education” (23-24 July, 2015) in Hansraj College, University of Delhi (Role: Coordinator). “1st International conference on emerging trends of nanotechnology in drug discovery” was organized (May 26-27, 2014) by Sri Venkateswara College & Department of Biochemistry, University of Delhi South Campus in association with Centro de Química da Madeira, Universidade da Madeira, Portugal (Role: National coordinator and organizing secretary). “A National Symposium on Recent Trends in Innovative Research at Under- graduation: Science and Society” was organized (28th Feb-2nd March 2013) by Sri Venkateswara College, University of Delhi (Role: Organizing secretary). A national seminar on Recent Trends in Chemistry” was organized (March 20-22, 2012) by Department of Chemistry, Sri Venkateswara College, University of Delhi (Role: Treasurer). A national conference on “Convergence of Science and Spirituality” was organized (5-6th Nov 2011) by Sri Venkateswara College in association with Institute for Science and Spirituality, A Study Wing of ISKCON Delhi (Role: Coordinator).

Talks

1. "Discovery of Multistage Antimalarials: Synergistic Fusion of Privileged Bioactive Scaffolds Triggers Growth Inhibition of Malaria Parasite Plasmodium Falciparum" Drug Discovery & Therapy World Congress (DDTWC-2017) July 10-13, 2017, Boston, MA United States of America. 2. "Functionalized Small Molecules As Potential Antimalarial Agents" National conference on Frontiers in Research & Development on Agriculture, Bio-medicinal, Chemical and Pharmaceutical sciences (4th March, 2016), Mewar University, Rajasthan. 3. Functionalized Phthalimides Enriched With Technological Applications’ International Conference on Recent Advances in Chemical Sciences (ICRACS 2013), Department of Chemistry, Arya P.G. College, Panipat, Haryana (24-26 February, 2013).

Workshop/ Conference/ Symposium ATTENDED

2016 MIT Digital Health Conference (September 7-8, 2016) organized by Massachusetts Institute of Technology, USA. Brijesh Rathi* “Peptide Nanoarchitechures Enriched with Biomedical Applications”, Indo-Portuguese workshop on Nanotechnology in Chemistry and Biology (INCB- 2016)” jointly organized by Department of Chemistry, Hansraj College and CQM, University of Madeira, Portugal (February 12-13, 2016). Brijesh Rathi* “Phthalimides as potential antimalarial agents embodying cyclic amine scaffolds” International Conference on Chemical Biology (ICCB-2014), CSIR-Indian Institute of Chemical Technology, Hyderabad (AP) INDIA (February 6-8, 2014). 1st International conference on emerging trends of nanotechnology in drug discovery (May 26-27, 2014). “International Conference on Recent Advances in Chemical Sciences” (ICRACS 2013), Department of Chemistry, Arya P.G. College, Panipat, Haryana (24-26 February, 2013). National/International Conferences Attended Indo-Portuguese workshop on Nanotechnology in Chemistry and Biology (INCB- 2016)” jointly organized by Department of Chemistry, Hansraj College and CQM, University of Madeira, Portugal (February 12-13, 2016). MHRD funded National Workshop on “Role of Technical Terminology in Higher Education” (23-24 July, 2015) in Hansraj College (University of Delhi). 7th edition of Nanoschool, from 6th to 9th October 2014, Centro de Química da Madeira, Universidade da Madeira, Campus da, Penteada, 9020-105 Funchal, PORTUGAL. Brijesh Rathi* “Phthalimides as potential antimalarial agents embodying cyclic amine scaffolds” International Conference on Chemical Biology (ICCB-2014), CSIR-Indian Institute of Chemical Technology, Hyderabad (AP) INDIA (February 6-8, 2014). 1st International conference on emerging trends of nanotechnology in drug discovery (INCB-2016) organized by Sri Venkateswara College and CQM, University of Madeira, Portugal (May 26-17, 2014). International Conferenceon Recent Advances in Chemical Sciences (ICRACS2013), Department of Chemistry, Arya P.G. College, Panipat, Haryana (24-26 February, 2013).

Others

Awards/Honors.

UGC-Raman International Fellowship (2016-2017) by Ministry of Human Recourses and Development, Govt. of India.

Early Carrier Research Award (2016-2019) by Science & Engineering Research Board (SERB), Ministry of Science of Technology, Govt. of India.

Felicitated for his contributions as coordinator of IISF-2015 by Cabinet Minister Dr. Harsh Vardhan, Govt. of India.

Young Scientist Fellowship (2011-2014) by DST, Ministry of Science of Technology, Govt. of India.

Reserach Collaborations.

Prof. Alexander M Klibanov, Novartis Chair Professor of Chemistry & Bioengineering, Massachusetts Institute of Technology, USA

Prof. Sangeeta Bhatia, Koch Institute, Massachusetts Institute of Technology, USA

Prof. Ben M Dunn, Distinguished Professor, Department of Biochemistry and Molecular Biology, University of Florida, USA

Prof. Daniel E. Goldberg, David M. and Paula L. Kipnis Distinguished Professo, University of Washington, USA 

Prof. DJ Perkins, Department of Internal Medicine, Center for Global Health, University of New Mexico School of Medicine, USA

Prof. Conor Caffrey, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, USA

Dr. KC Pandey, National Institute of Malaria Research, India 

Prof. Vladimir A. Korshun, Director, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya, 16/10, Moscow, RUSSIA

Honorary Positions (Editing/Review/Membership of Scientific Bodies.

  1. Section Editor, Current Topics in Medicinal Chemistry (Bentham Science Publisher; IF: 2.90).
  2. Editorial Review Board Member, ARKIVOC, Arkat USA.

  3. Editorial Member, "Journal of Nano Education" Published by American Scientific Publishers, USA.

  4. Editorial Member, American Journal of Applied Chemistry” Published by 
Science Publishing Group, New York, USA. 

  5. Editorial Member, “American Journal of Nanoscience and Nanotechnology” Published by Science Publishing Group, New York, USA.



  6. Editorial Member, “Chemical Biology Letters” Published by Indian Science Publications.
  7. Reviewer, BIOCHEMISTRY; RSC Advances; Microbial Pathogenesis; Journal of Heterocyclic Chemistry; Bioorganic Medicinal Chemistry; ARKIVOC etc.
  8. Jury Member, DST Inspire 2015.

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